In 1973, neuroscientists Timothy V. P. Bliss and Terje Lømo published a landmark paper demonstrating what they termed long-lasting enhancement of synaptic transmission in the hippocampus of anesthetized rabbits, work that became known as Long-Term Potentiation (LTP), showing that brief, high-frequency stimulation of the perforant path produced enduring increases in synaptic strength in the dentate gyrus, thereby offering the first compelling physiological model for learning and memory. Their experiments, conducted in Oslo in the early 1970s and published in 1973, provided concrete evidence that experience can produce persistent changes in neural connectivity, helping to bridge Donald Hebb’s earlier theoretical proposal (1949) that “cells that fire together wire together” with measurable biological mechanisms. From a Christian perspective, this discovery resonates deeply with the Biblical affirmation that humans are embodied souls (Genesis 2:7) whose minds are capable of renewal and transformation (“be transformed by the renewing of your mind,” Romans 12:2), suggesting that God designed the brain with plastic capacities that enable growth in wisdom, virtue, and love through repeated practice, discipleship, and community. Theologians such as Augustine and Thomas Aquinas emphasised the formation of habits (virtues) through repeated action, a concept strikingly consonant with LTP’s demonstration that repetition strengthens pathways, though Christians would also maintain that neural plasticity is a mechanism within creation rather than a reduction of personhood to biology, preserving the imago Dei (Genesis 1:27). For personal wellbeing, LTP research undergirds evidence-based approaches to learning, psychotherapy, rehabilitation, and spiritual disciplines by explaining how consistent practice reshapes the brain, fostering resilience and cognitive flourishing. For societal health, it informs education policy, trauma recovery, and public health strategies, highlighting that environments of enrichment, stability, and moral formation can literally strengthen the neural foundations of thriving communities.