In 1921, Austrian physiologist Otto Loewi performed his famous frog-heart experiment, stimulating the vagus nerve of one isolated heart to slow it, transferring the surrounding perfusate to a second heart, and observing the same slowing, which demonstrated that nerve signals could be transmitted by a diffusible chemical he called Vagusstoff, thereby establishing chemical neurotransmission and overturning the prevailing assumption that neural communication was purely electrical; subsequent work identified Vagusstoff as acetylcholine (ACh), a neurotransmitter whose actions had been independently anticipated by Thomas R. Elliott’s 1904 proposal of chemical mediation, experimentally characterized by Henry H. Dale and colleagues in the 1910s (including the isolation and pharmacology of ACh), and further elucidated by Otto Feldberg, with Loewi and Dale jointly awarded the Nobel Prize in Physiology or Medicine in 1936 for this discovery. From a Christian perspective, Loewi’s work can be viewed as uncovering the elegant order of God’s creation (“fearfully and wonderfully made” Psalm 139:14), wherein precise chemical messengers sustain life, echoing the biblical affirmation that creation is intelligible and worthy of careful stewardship (Genesis 1:28; Proverbs 25:2), and that truth discovered through humble inquiry can serve love of neighbour (Matthew 22:39). The value of this discovery for personal wellbeing and societal health is immense: understanding ACh underpins treatments for cardiovascular disease, myasthenia gravis, Alzheimer’s disease, anaesthesia, and mental health, enabling relief of suffering and promoting human flourishing, thus aligning scientific insight with ethical responsibility to heal, protect life, and foster the common good.