In 1874, Carl Wernicke transformed neuroscience by identifying a region of the posterior superior temporal gyrus essential for language comprehension, now called Wernicke’s area, after observing patients who could speak fluently yet produced meaningless speech and failed to understand language, a pattern he linked to focal brain lesions (Wernicke, 1874). His work built on Paul Broca’s earlier localisation of speech production in the left frontal lobe (Broca, 1861) and was extended by Ludwig Lichtheim’s connectionist model of aphasia (Lichtheim, 1885), later synthesised and popularised in the twentieth century by Norman Geschwind’s revival of disconnection syndromes (Geschwind, 1965). From a Christian perspective, Wernicke’s discovery illuminates the intricate, God-given unity of mind and body, echoing the Biblical affirmation that humans are “fearfully and wonderfully made” (Psalm 139:14) and that language itself is a divine gift enabling relationship, meaning, and moral responsibility (Genesis 1:26–28; Proverbs 18:21). Understanding how comprehension can be selectively impaired underscores human dependence and finitude after the Fall (Romans 8:20–23), while also affirming the call to compassionate care for those who suffer (Luke 10:33–35). Practically, this work has profoundly benefited personal wellbeing and societal health by improving diagnosis and rehabilitation of aphasia, guiding speech–language therapy, informing education and stroke care, and fostering empathy for communication disorders, thereby strengthening families, communities, and healthcare systems through clearer understanding, restored participation, and more humane responses to neurological illness.