From a Christian perspective, the most fundamental personal life strategy is to love, seek, and orient one's whole life toward God, because humanity was created for communion with Him and finds its deepest integration, purpose, and flourishing only in that relationship (Deuteronomy 6:4–5; Matthew 22:37–38; John 15:1–11; Augustine, Confessions, I.1).

Christian psychology has consistently argued that theocentric living provides the organising centre of personality, promoting coherence, meaning, moral development, resilience, and psychological wellbeing, whereas rejection of this foundational orientation leaves the individual more vulnerable to fragmentation, existential emptiness, maladaptive coping, and a broad range of psychopathologies, not because every mental disorder is caused by lack of faith, but because alienation from God removes the ultimate source of identity, hope, and spiritual integration in the Christian understanding of the person.

Among the most influential contributors, Gary R. Collins (1988) argued that psychological wholeness is inseparable from spiritual maturity and relationship with God. Mark R. McMinn (1996, 2011) demonstrated that authentic Christian spirituality provides an essential framework for integrating psychological practice with spiritual formation. Eric L. Johnson (2007) developed a comprehensive Christian psychology rooted in Biblical anthropology, arguing that the knowledge of God is foundational for understanding healthy personality and psychological functioning. Siang-Yang Tan (2011) emphasised that spiritual disciplines, prayer, and loving communion with God contribute to emotional healing and resilience. Malcolm A. Jeeves and Warren S. Brown (2009) argued that a Biblically informed understanding of persons integrates biological, psychological, social, and spiritual dimensions into a unified account of human flourishing.

Theologically, Scripture portrays the fear and love of God as "the beginning of wisdom" (Proverbs 9:10), teaches that believers are transformed through renewal of the mind (Romans 12:2), and affirms that "in him all things hold together" (Colossians 1:17), suggesting that Christ is the ultimate integrating principle of human existence. Consequently, Christian psychology maintains that while mental illness is multifactorial and includes genetic, neurological, developmental, relational, and environmental causes, enduring psychological wellbeing reaches its fullest expression when the whole person is rightly ordered in love toward God. In contrast, persistent estrangement from God may contribute to spiritual disintegration that can increase vulnerability to despair, anxiety, disordered identity, addictive behaviours, and other forms of psychological dysfunction. At the same time, it is recognised that faithful Christians may also experience mental illness requiring compassionate pastoral, psychological, and medical care.